Name: Jacques Daniel

My Area of Interest: Functioning of macromolecular networks in the yeast model eukaryote; early stages of drug discovery and development; evolution of biological complexity

My Favourite Quote: Let educated intuition, not conformity, be our guide

I am a: Charge de Recherche at the Centre National de la Recherche Scientifique (CNRS, France)

Short Profile:

What are your future goals? Where do you see your research going?:
Building up automatic platforms for:
- The systematic study of cell’s macromolecular functional interactions
- Drug lead discovery targeted at any specific protein.
Theoretical research: the building up of cellular and organismal machines during evolution

Technologies seem to changing faster than ever, how do you adapt to that? What are the current technologies you are using?:
Large-scale systems-biology approach (i.e. fitness-based interferential genetics and derivative) for deciphering the functional interactions occurring between the macromolecular components of a eukaryotic cell.

In the broader picture, where do you see the application for your cutting-edge research?:
- Toward the complete mapping and understanding of a eukaryotic cell’s functioning; application to the core functioning of mammalian cells; predictions for incisive therapeutic interventions, for example in various out-of-control cell processes correlated with specific diseases.
- Drug lead compound research targeted at specific proteins.

Fast forward to 2020. What’s your vision of Genomics in 2020?:
Predictive cell physiology by means of the complete mapping and understanding of macromolecular functional interactions then obtained, and of the use, in the cell context, of a whole spectrum of macromolecular-activity modifiers.
Studying how diseases at various stages of their development correlate with the state of the cell’s macromolecular networks.
Personalized genomics and cell physiology study aimed at disease’s prevention or cure.