Name: Sudha Sazawal

My Area of Interest: Functional Genomics

My Favourite Quote: Work is worship

I am a: Senior Scientist

Short Profile:

Question and Answers :

What are your future goals? Where do you see your research going?:
Primarily my work involves routine patient care by monitoring CML patients, treated with Imatinib, by real time PCR for BCR-ABL mRNA This technique has proved effective for defining patient response, hence assure rational therapeutic management of CML patients.
Apart from this it is important to clarify the mechanism underlying the disease progression in CML patients. We therefore plan to characterize the stage progression in different phases of the disease by DNA microarray.

Technologies seem to changing faster than ever, how do you adapt to that? What are the current technologies you are using?:
We are currently using real-time PCR for routine monitoring of CML patients. Our next step is modulation of genes to understand the biology of this disease.

In the broader picture, where do you see the application for your cutting-edge research?:
The application is mainly to elucidate the molecular mechanism responsible for the drug resistance in these patients by understanding the biology of stage progression in these patients. DNA microarray allows characterization of the expression profiles of many genes that might prove informative for stage diagnosis or contribute to stage progression. Thus determining appropriate new therapy to prevent or overcome resistance.

Fast forward to 2020. What’s your vision of Genomics in 2020?:
The growing body of genome information can help in a general way to address global problems by applying a comparative approach. It can help identification of genes for regulatory RNAs or estimation of the contribution of horizontal gene transfer to the genomes that have been analyzed.