Articles Archive for November 2009
Featured »
This case study details biomarker qualification strategies in CNS diseases using Gene Logic’s BioExpress® System.
You will learn about:
- Tracing of dysregulated genes from post-mortem brain tissue to peripheral blood
- Determination of whether the above gene changes are disease specific
- Identification of genes that are related to aging rather than to CNS disease
Author: Jarlath ffrench-Mullen, PhD, Scientific Director, Gene Logic.
On the Trail »
Department of Molecular and Human Genetics - Baylor College of Medicine
“What I can say is that structural changes, and in particular CNVs, may indeed be responsible for a lot of sporadic disease given the fact that locus specific mutation rates for CNV mutations can be 100 to 10,000 times more frequent than locus specific mutation rates for single base pair changes or SNPs (single nucleotide polymorphisms). It may also be that the nervous system in particular is more susceptible to copy number changes than other biochemical pathways, or networks of interacting proteins in different physiological systems, within the body.”
On the Trail »
Principal Scientist, Discovery Technologies and Infectious Diseases - Glaxo Smithkline
“Larger studies and extensive clinical validation will help to identify miRNAs that have true diagnostic value. From our experience and published reports, microRNA profiles have appeared to be more useful in terms of their diagnostic value than messenger RNA profiles. The fact that miRNAs are stable in FFPE (formalin-fixed paraffin embedded) tissue samples opens up a wider array of available diagnostic specimens for such validations. Poor stability of messenger RNA in FFPE samples and the ability to amplify it has been an issue for doing such kinds of transcriptomic studies. Being able to go back to older archived tissues from patients with known clinical outcomes obviously allows you to do the kinds of studies that are needed to validate the diagnostic and predictive value of a particular profile. Recent advances in technology for detection of microRNA have pushed the ability to detect levels from even a single cell so even samples with limited material are possible to evaluate now.”
Genomics Gateway »
This dashboard serves as an interactive platform for the Genomic Pioneer members. Over a period of time we can reflect back on the threads to perhaps review how the field of genomics is shaping up through our eyes. That will be interesting to see!
You do not need any sign up or give any personal information. Just pick a screen name and start typing! What are you waiting for? Get started:) Just remember this URL to come back again.
http://etherpad.com/roT866i6Ls
Some ideas to use this dashboard:
* Introducing ourselves and share interesting information about our interests, findings, anything scientific really!
* Rate interesting genomics papers and share it with the users.
* Share/Review interesting papers and stuff you came across.
* Share information and get feedback on your work
* Share and rekindle classic science which has got lost over the years
* Start a debate on a burning topic of interest!
* We will also use this platform to hold interactive sessions with key thought leaders and use it for our regular -OMICs Saturday chats!
*You can also talk live to other genomics folks online.
Any more ideas Pioneers?
cheers,
Ashwin
